Entropy-Weighted Collapse Likelihood (EWCL)
Proteins explore ensembles of microstates rather than a single conformation. EWCL maps residue-level conformational entropy on [0,1] directly from sequence, quantifying the likelihood that a locus remains ensemble-like versus collapsed. The score complements geometry-first confidences (e.g., pLDDT) with a thermodynamic perspective that's interpretable across proteins — useful for triaging flexible segments, linkers, and collapse-prone regions in practical analysis workflows.
Entropy-Weighted Collapse Likelihood (EWCL)
Proteins explore ensembles of microstates rather than a single conformation. EWCL maps residue-level conformational entropy on [0,1] directly from sequence, quantifying the likelihood that a locus remains ensemble-like versus collapsed. The score complements geometry-first confidences (e.g., pLDDT) with a thermodynamic perspective that's interpretable across proteins — useful for triaging flexible segments, linkers, and collapse-prone regions in practical analysis workflows.