EWCL

EWCL: Entropy-Weighted Collapse Likelihood

A statistical framework to detect structural disorder and collapse risk from entropic signals in 29,312 proteins.

Start AnalysisEWCL B-Factor Collapse Overview

Validated on

29,312

proteins

pLDDT Correlation

r = 0.928

B-Factor Correlation

r = 0.947

DisProt AUC

0.761

ClinVar Recall

0.807

EWCL Validation Highlights
Based on 29,312 experimentally derived protein structures

EWCL benchmark validation results

EWCL achieves high correlation with experimental and predicted metrics across 13,855 benchmarked structures. Validated across 29,312 curated protein structures.

Benchmark validated on 29,312 curated proteins. Full results available in the About section or download ZIP →

Explore EWCL in 3D

AI-Powered Mutation Prioritization

Our Random Forest classifier combines EWCL collapse scores with mutation data to triage pathogenic variants.

0.56Precision
0.45Recall
0.50F1-Score
0.71ROC AUC

🧬 EWCL highlights 80.7% of ClinVar pathogenic variants in collapse-prone regions

🔍 BRCA1: 73.2% • CHEK2: 43.3%

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